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PHYS 699:
Mathematical Modelling of Immune Dynamics
(Winter 2003)


(Click here for Fall 2002)


Under the supervision of:

Dr. Jack Tuszynski jtus@phys.ualberta.ca 492-3579
Dr. John Samuel jsamuel@pharmacy.ualberta.ca 492-7469



Report:

Latest version: immuno2.pdf (not finished)



Schedule:

March 21, 2003 Last meeting with Jack and John. It was decided that mark for the reading course would be assigned for a final project to be presented to them at the end of May. Any additional reading done to complete the final project will be posted.
March 11, 2003 Meeting with John about MHC and read articles.
February 27, 2003 Assigned reading:
  1. D. J. Smith, S. Forrest, D. H. Ackley, and A. S. Perelson. Variable efficacy of repeated annual influenza vaccination. Proc. Natl. Acad. Sci. USA, 96:14001-14006, 1999.

  2. Derek J. Smith, Alan S. Lapedes, Stephanie Forrest, Jan C. deJong, Albert D. M. E. Osterhaus, Ron A. M. Fouchier, Nancy J. Cox, and Alan S. Perelson. Modeling the effects of updating the influenza vaccine on the efficacy of repeated vaccination. In A. D. M. E. Osterhaus, N. J. Cox, and A. W. Hampson, editors, Options for the Control of Influenza Virus IV, volume 1219 of International Congress Series pp. 655-660, Amsterdam, 2001. Excerpta Medica (Elsevier). Proceedings of the World Congress on Options for the Control of Influenza Virus IV, Crete, Greece, 23-28 September 2000.
No meeting.
February 20, 2003 Assigned reading:
  1. J. K. Percus, O. E. Percus, and A. S. Perelson. Predicting the size of the T-cell receptor and antibody combining region from consideration of efficient self-nonself discrimination. Proc. Natl. Acad. Sci. USA, 90:1691-1695, 1993.

  2. R. R. Hightower, S. Forrest, and A. S. Perelson. The evolution of emergent organization in immune system gene libraries. In L. J. Eshelman, editor, Proceedings of the 6th International Conference on Genetic Algorithms, pp. 344-350, San Francisco, CA, 1995. Morgan Kaufman

  3. R. R. Hightower, S. Forrest, and A. S. Perelson. The Baldwin effect in the immune system: Learning by somatic hypermutation. In R. K. Belew and M. Mitchell, editors, Adaptive Individuals in Evolving Populations, pp. 159-167, Addison-Wesley, Reading, MA, 1996.

No meeting (reading week).
February 13, 2003 Assigned reading:
  • "Kuby Immunology 4th Edition", Chapter 7: MHC.
Reading with John about chromosomes, alleles, etc.
February 6, 2003 Assigned reading:
  • "Kuby Immunology 4th Edition", Chapter 9: TCR.
Reading with John about DNA, RNA, genes, etc.
January 30, 2003 Assigned reading:
  • "Kuby Immunology 4th Edition", Chapter 5: B-cell receptors.
Reading with Jack about ribbon/ball-and-stick/space filling diagrams.
January 23, 2003 Assigned reading:
  • "Kuby Immunology 4th Edition", Chapter 4: Ig structure
    (of interest: antigen structure and ribbon diagrams).
January 16, 2003 Assigned reading:
  • N. Jerne, "Towards a network theory of the immune system", Ann. Immunol. (Inst. Pasteur) 125C, 373-389, 1974.



Interesting links:




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